Heard this while watching a TVB drama recently.

你知不知道男人最痛是什么？
It is when he is no longer physically close to his loved one and yet still emotionally bonded to her.

然后女人最痛是什么？
是相反的！

Agreeable, no? I think it's quite true since women are usually more emotionally attached while men are more of the other way round.